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1

Enhanced expression of cystine/glutamate transporter in the lung caused by the oxidative-stress-inducing agent paraquat

Sho Kobayashi, Kazuho Kuwata, Takayuki Sugimoto, Kiharu Igarashi, Mitsuhiko Osaki, Futoshi Okada, Junichi Fujii, Shiro Bannai, Hideyo Sato

Journal:

Free Radical Biology and Medicine

Year:

2012

Language:

english

File:

PDF, 856 KB

english, 2012

2

Expression of p21 (waf1/cip1/sdi1), but not p53 protein, is a factor in the survival of patients with advanced gastric carcinoma

Yoshihito Gomyo, Mitsuyuki Ikeda, Mitsuhiko Osaki, Shigeru Tatebe, Shunichi Tsujitani, Masahide Ikeguchi, Nobuaki Kaibara, Hisao Ito

Journal:

Year:

1997

Language:

english

File:

PDF, 167 KB

english, 1997

3

Numerical aberration and point mutation of p53 gene in human gastric intestinal metaplasia and well-differentiated adenocarcinoma: Analysis by fluorescence in situ hybridization (FISH) and PCR-SSCP

Yoshihito Gomyo, Mitsuhiko Osaki, Nobuaki Kaibara, Hisao Ito

Journal:

International Journal of Cancer

Year:

1996

Language:

english

File:

PDF, 799 KB

english, 1996

4

Low frequency of apoptosis in Epstein-Barr virus-associated gastric carcinoma with lymphoid stroma

Satoshi Ohfuji, Mitsuhiko Osaki, Shunichi Tsujitani, Masahidc Ikeguchi, Takeshi Sairenji, Hisao Ito

Journal:

International Journal of Cancer

Year:

1996

Language:

english

File:

PDF, 942 KB

english, 1996

5

The distinct role of the Runx proteins in chondrocyte differentiation and intervertebral disc degeneration: Findings in murine models and in human disease

Shingo Sato, Ayako Kimura, Jerfi Ozdemir, Yoshinori Asou, Makiko Miyazaki, Tetsuya Jinno, Keisuke Ae, Xiuyun Liu, Mitsuhiko Osaki, Yasuhiro Takeuchi, Seiji Fukumoto, Hiroshi Kawaguchi, Hirotaka Haro,

Journal:

Arthritis & Rheumatism

Year:

2008

Language:

english

File:

PDF, 1.87 MB

english, 2008

6

Solitary hepatic tuberculoma with chronic hepatitis C diagnosed by polymerase chain reaction using paraffin-embedded resected specimen

Naoto Maeda, Shinsuke Tanaka, Hironobu Andachi, Mitsuhiko Osaki, Yutaka Horie, Takeaki Suou, Hironaka Kawasaki

Journal:

Hepatology Research

Year:

1999

Language:

english

File:

PDF, 822 KB

english, 1999

7

Minichromosome maintenance 2 expression is correlated with mode of invasion and prognosis in oral squamous cell carcinomas

Isamu Kodani, Mitsuhiko Osaki, Kohei Shomori, Kunio Araki, Eizo Goto, Kazuo Ryoke, Hisao Ito

Journal:

Journal of Oral Pathology & Medicine

Year:

2003

Language:

english

File:

PDF, 156 KB

english, 2003

8

Proteomic identification of differentially-expressed genes in human gastric carcinomas

Ryuichi Nishigaki, Mitsuhiko Osaki, Masaharu Hiratsuka, Tosifusa Toda, Kaori Murakami, Kuan-Teh Jeang, Hisao Ito, Toshiaki Inoue, Mitsuo Oshimura

Journal:

Year:

2005

Language:

english

File:

PDF, 630 KB

english, 2005

9

Evaluation of the antiangiogenic effect of Taxol in a human epithelial ovarian carcinoma cell line

Kohkichi Hata, Mitsuhiko Osaki, Dipok Kumar Dhar, Kentaro Nakayama, Ritsuto Fujiwaki, Hisao Ito, Naofumi Nagasue, Kohji Miyazaki

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2004

Language:

english

File:

PDF, 1023 KB

english, 2004

10

Evaluation of the antiangiogenic effect of Taxol in a human epithelial ovarian carcinoma cell line

Kohkichi Hata, Mitsuhiko Osaki, DipokKumar Dhar, Kentaro Nakayama, Ritsuto Fujiwaki, Hisao Ito, Naofumi Nagasue, Kohji Miyazaki

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2004

Language:

english

File:

PDF, 293 KB

english, 2004

11

MAD1 (mitotic arrest deficiency 1) is a candidate for a tumor suppressor gene in human stomach

Mitsuhiko Osaki, Toshiaki Inoue, Shigeyuki Yamaguchi, Aiko Inaba, Naruo Tokuyasu, Kuan-Teh Jeang, Mitsuo Oshimura, Hisao Ito

Journal:

Virchows Archiv

Year:

2007

Language:

english

File:

PDF, 567 KB

english, 2007

12

Thymidine phosphorylase expression results in a decrease in apoptosis and increase in intratumoral microvessel density in human gastric carcinomas

Mitsuhiko Osaki, Takashi Sakatani, Eiji Okamoto, Eizou Goto, Hironobu Adachi, H. Ito

Journal:

Virchows Archiv

Year:

2000

Language:

english

File:

PDF, 363 KB

english, 2000

13

Inhibition of the PI3K-Akt signaling pathway enhances the sensitivity of Fas-mediated apoptosis in human gastric carcinoma cell line, MKN-45

Mitsuhiko Osaki, Satoru Kase, Keiko Adachi, Ami Takeda, Kiyoshi Hashimoto, Hisao Ito

Journal:

Journal of Cancer Research and Clinical Oncology

Year:

2004

Language:

english

File:

PDF, 328 KB

english, 2004

14

Expression of Fas and Fas ligand in human gastric adenomas and intestinal-type carcinomas: correlation with proliferation and apoptosis

Mitsuhiko Osaki, Satoru Kase, Isamu Kodani, Mari Watanabe, Hironobu Adachi, Hisao Ito

Journal:

Year:

2001

Language:

english

File:

PDF, 256 KB

english, 2001

15

Tubular adenoma and intramucosal intestinal-type adenocarcinoma of the stomach: what are the pathobiological differences?

Satoru Kase, Mitsuhiko Osaki, Soichiro Honjo, Hironobu Adachi, Hisao Ito

Journal:

Year:

2003

Language:

english

File:

PDF, 667 KB

english, 2003

16

Cytochrome P450 aromatase gene (CYP19) expression in gastric cancer

Masao Izawa, Masashi Inoue, Mitsuhiko Osaki, Hisao Ito, Tasuku Harada, Naoki Terakawa, Masahide Ikeguchi

Journal:

Year:

2008

Language:

english

File:

PDF, 611 KB

english, 2008

17

Expression of Fas Antigen and Its Mediation of Apoptosis in Human Gastric Cancer Cell Lines

Hisae Hayashi, Shigeru Tatebe, Mitsuhiko Osaki, Akira Goto, Yoshimasa Suzuki, Hisao Ito

Journal:

Year:

1997

File:

PDF, 393 KB

1997

18

Expression of RUNX3 protein in human lung adenocarcinoma: Implications for tumor progression and prognosis

Kunio Araki, Mitsuhiko Osaki, Yumi Nagahama, Toshiki Hiramatsu, Hiroshige Nakamura, Shigetsugu Ohgi, Hisao Ito

Journal:

Year:

2005

Language:

english

File:

PDF, 178 KB

english, 2005

19

Apoptotic pathway induced by transduction of RUNX3 in the human gastric carcinoma cell line MKN-1

Yumi Nagahama, Mika Ishimaru, Mitsuhiko Osaki, Toshiaki Inoue, Akihiro Maeda, Chisato Nakada, Masatsugu Moriyama, Kenzo Sato, Mitsuo Oshimura, Hisao Ito

Journal:

Year:

2008

Language:

english

File:

PDF, 306 KB

english, 2008

20

SIRT2 down-regulation in HeLa can induce p53 accumulation via p38 MAPK activation-dependent p300 decrease, eventually leading to apoptosis

Yanze Li, Haruka Matsumori, Yuji Nakayama, Mitsuhiko Osaki, Hirotada Kojima, Akihiro Kurimasa, Hisao Ito, Seiichi Mori, Motonobu Katoh, Mitsuo Oshimura, Toshiaki Inoue

Journal:

Year:

2011

Language:

english

File:

PDF, 811 KB

english, 2011

21

Rapid hepatic fate specification of adipose-derived stem cells and their therapeutic potential for liver failure

Agnieszka Banas, Takumi Teratani, Yusuke Yamamoto, Makoto Tokuhara, Fumitaka Takeshita, Mitsuhiko Osaki, Takashi Kato, Hitoshi Okochi, Takahiro Ochiya

Journal:

Journal of Gastroenterology and Hepatology

Year:

2009

Language:

english

File:

PDF, 825 KB

english, 2009

22

Arpp, a New Homolog of Carp, Is Preferentially Expressed in Type 1 Skeletal Muscle Fibers and Is Markedly Induced by Denervation

Tsukamoto, Yoshiyuki, Senda, Takao, Nakano, Toshiya, Nakada, Chisato, Hida, Takehiko, Ishiguro, Naoko, Kondo, Gento, Baba, Takeshi, Sato, Kenzo, Osaki, Mitsuhiko

Journal:

Laboratory Investigation

Year:

2002

Language:

english

File:

PDF, 3.58 MB

english, 2002

23

IFATS Collection: In Vivo Therapeutic Potential of Human Adipose Tissue Mesenchymal Stem Cells After Transplantation into Mice with Liver Injury

Agnieszka Banas, Takumi Teratani, Yusuke Yamamoto, Makoto Tokuhara, Fumitaka Takeshita, Mitsuhiko Osaki, Masaki Kawamata, Takashi Kato, Hitoshi Okochi, Takahiro Ochiya

Journal:

Year:

2008

Language:

english

File:

PDF, 1.23 MB

english, 2008

24

Expression of cyclo-oxygenase-2 is correlated with high intratumoral microvessel density and low apoptotic index in human esophageal squamous cell carcinomas

Satoru Kase,Mitsuhiko Osaki,Soichiro Honjo,Hironobu Adachi…

Journal:

Virchows Archiv

Year:

2003

Language:

english

File:

PDF, 269 KB

english, 2003

25

Cyclo-oxygenase-1 and -2 expression in human oral mucosa, dysplasias and squamous cell carcinomas and their pathological significance

Masami Shibata, Isamu Kodani, Mitsuhiko Osaki, Kunio Araki, Hironobu Adachi, Kazuo Ryoke, Hisao Ito

Journal:

Year:

2005

Language:

english

File:

PDF, 365 KB

english, 2005

26

Runt-related transcription factor 3 expression in human oral squamous cell carcinomas; implication for tumor progression and prognosis

Yoshiyuki Tanji, Mitsuhiko Osaki, Yumi Nagahama, Isamu Kodani, Kazuo Ryoke, Hisao Ito

Journal:

Year:

2007

Language:

english

File:

PDF, 1.17 MB

english, 2007

27

High expression of EZH2 is associated with tumor proliferation and prognosis in human oral squamous cell carcinomas

Kazunori Kidani, Mitsuhiko Osaki, Takayuki Tamura, Kensaku Yamaga, Kohei Shomori, Kazuo Ryoke, Hisao Ito

Journal:

Year:

2009

Language:

english

File:

PDF, 549 KB

english, 2009

28

Thymidine phosphorylase expression causes both the increase of intratumoral microvessels and decrease of apoptosis in human esophageal carcinomas

Eiji Okamoto, Mitsuhiko Osaki, Satoru Kase, Hironobu Adachi, Nobuaki Kaibara, Hisao Ito

Journal:

Pathology International

Year:

2001

Language:

english

File:

PDF, 687 KB

english, 2001

29

Prostatic stromal sarcoma: Case report and review of the literature

Mari Osaki, Mitsuhiko Osaki, Chihiro Takahashi, Tetsuo Miyagawa, Hironobu Adachi, Hisao Ito

Journal:

Pathology International

Year:

2003

Language:

english

File:

PDF, 372 KB

english, 2003

30

Expression of thymidine phosphorylase in choroidal malignant melanoma associated with neovascular glaucoma

Satoru Kase, Wataru Saito, Kazuhiko Yoshida, Kenichi Namba, Mitsuhiko Osaki, Kazuhiro Ohgami, Kenji Shiratori, Nobuyoshi Kitaichi, Hironobu Adachi, Hisao Ito, Shigeaki Ohno

Journal:

Pathology International

Year:

2005

Language:

english

File:

PDF, 220 KB

english, 2005

31

Induction of efficient apoptosis and cell-cycle arrest in tumor cells by adenovirus-mediated p53 A4 mutant

Akihiro Maeda, Seiichi Nakamura, Masato Isono, Mitsuhiko Osaki, Hisao Ito, Kenzo Sato

Journal:

Pathology International

Year:

2006

Language:

english

File:

PDF, 412 KB

english, 2006

32

Complete Genetic Correction of iPS Cells From Duchenne Muscular Dystrophy

Kazuki, Yasuhiro, Hiratsuka, Masaharu, Takiguchi, Masato, Osaki, Mitsuhiko, Kajitani, Naoyo, Hoshiya, Hidetoshi, Hiramatsu, Kei, Yoshino, Toko, Kazuki, Kanako, Ishihara, Chie

Journal:

Molecular Therapy

Year:

2009

Language:

english

File:

PDF, 892 KB

english, 2009

33

A new chromosome 14-based human artificial chromosome (HAC) vector system for efficient transgene expression in human primary cells

Minoru Kakeda, Keiko Nagata, Kanako Osawa, Hiroki Matsuno, Masaharu Hiratsuka, Akiko Sano, Akiyo Okazaki, Shingo Shitara, Satoshi Nishikawa, Anri Masuya, Toshihiro Hata, Shun Wako, Mitsuhiko Osaki, Ya

Journal:

Biochemical and Biophysical Research Communications

Year:

2011

Language:

english

File:

PDF, 591 KB

english, 2011

34

Immunohistochemical analysis of a muscle ankyrin-repeat protein, Arpp, in paraffin-embedded tumors: evaluation of Arpp as a tumor marker for rhabdomyosarcoma

Naoko Ishiguro, Toru Motoi, Mitsuhiko Osaki, Nobuhito Araki, Takeshi Minamizaki, Masatsugu Moriyama, Hisao Ito, Haruhiko Yoshida

Journal:

Human Pathology

Year:

2005

Language:

english

File:

PDF, 359 KB

english, 2005

35

Carp, a Cardiac Ankyrin-Repeated Protein, and Its New Homologue, Arpp, Are Differentially Expressed in Heart, Skeletal Muscle, and Rhabdomyosarcomas

Naoko Ishiguro, Takeshi Baba, Tsuyoshi Ishida, Kengo Takeuchi, Mitsuhiko Osaki, Nobuhito Araki, Eikichi Okada, Satsuki Takahashi, Masahiro Saito, Mari Watanabe, Chisato Nakada, Yoshiyuki Tsukamoto, Ke

Journal:

The American Journal of Pathology

Year:

2002

Language:

english

File:

PDF, 2.42 MB

english, 2002

36

Intraosseous Schwannoma of the Mandible

Isamu Kodani, Yoshiya Ueyama, Tatsuyuki Mori, Rieko Doi, Mitsuhiko Osaki, Satoshi Kataoka, Mitsugi Onda, Hirofumi Sakamoto, Masami Shibata, Hisao Ito, Kazuo Ryoke

Journal:

Asian Journal of Oral and Maxillofacial Surgery

Year:

2003

Language:

english

File:

PDF, 454 KB

english, 2003

37

Co-expression of Cox-2 and EGFR in stage I human bronchial adenocarcinomas

Araki, Kunio, Hashimoto, Kiyoshi, Ardyanto, Tonang Dwi, Osaki, Mitsuhiko, Shomori, Kohei, Nakamura, Hiroshige, Ito, Hisao

Journal:

Year:

2004

Language:

english

File:

PDF, 340 KB

english, 2004

38

Expression of Minichromosome Maintenance 2 (MCM2), Ki-67, and Cell-Cycle-Related Molecules, and Apoptosis in the Normal-Dysplasia-Carcinoma Sequence of the Oral Mucosa

Kodani, Isamu, Shomori, Kohei, Osaki, Mitsuhiko, Kuratate, Itaru, Ryoke, Kazuo, Ito, Hisao

Journal:

Year:

2001

Language:

english

File:

PDF, 568 KB

english, 2001

39

Systemic Delivery of Synthetic MicroRNA-16 Inhibits the Growth of Metastatic Prostate Tumors via Downregulation of Multiple Cell-cycle Genes

Takeshita, Fumitaka, Patrawala, Lubna, Osaki, Mitsuhiko, Takahashi, Ryou-u, Yamamoto, Yusuke, Kosaka, Nobuyoshi, Kawamata, Masaki, Kelnar, Kevin, Bader, Andreas G., Brown, David, Ochiya, Takahiro

Journal:

Molecular Therapy

Year:

2010

Language:

english

File:

PDF, 373 KB

english, 2010

40

COX-2 Inhibitor, NS398, Enhances Fas-Mediated Apoptosis via Modulation of the PTEN–Akt Pathway in Human Gastric Carcinoma Cell Lines

Honjo, Soichiro, Osaki, Mitsuhiko, Ardyanto, Tonang Dwi, Hiramatsu, Toshiki, Maeta, Noritaka, Ito, Hisao

Journal:

DNA and Cell Biology

Year:

2005

Language:

english

File:

PDF, 225 KB

english, 2005

41

Chronic inflammation-derived nitric oxide causes conversion of human colonic adenoma cells into adenocarcinoma cells

Tazawa, Hiroshi, Kawaguchi, Tokuichi, Kobayashi, Tokushige, Kuramitsu, Yasuhiro, Wada, Sayori, Satomi, Yoshiko, Nishino, Hoyoku, Kobayashi, Masanobu, Kanda, Yusuke, Osaki, Mitsuhiko, Kitagawa, Tomoyuk

Journal:

Experimental Cell Research

Year:

2013

Language:

english

File:

PDF, 2.94 MB

english, 2013

42

Circulating MicroRNAs in Drug Safety Assessment for Hepatic and Cardiovascular Toxicity: The Latest Biomarker Frontier?

Osaki, Mitsuhiko, Kosaka, Nobuyoshi, Okada, Futoshi, Ochiya, Takahiro

Journal:

Molecular Diagnosis & Therapy

Year:

2014

Language:

english

File:

PDF, 286 KB

english, 2014

43

MicroRNA-143 Regulates Human Osteosarcoma Metastasis by Regulating Matrix Metalloprotease-13 Expression

Osaki, Mitsuhiko, Takeshita, Fumitaka, Sugimoto, Yui, Kosaka, Nobuyoshi, Yamamoto, Yusuke, Yoshioka, Yusuke, Kobayashi, Eisuke, Yamada, Tesshi, Kawai, Akira, Inoue, Toshiaki, Ito, Hisao, Oshimura, Mit

Journal:

Molecular Therapy

Year:

2011

Language:

english

File:

PDF, 328 KB

english, 2011

44

1053. Functional Restoration of a Genetic Defect in Multipotent Germline Stem Cells by Human Artificial Chromosome Containing a Genomic Insert

Kazuki, Yasuhiro, Hoshiya, Hidetoshi, Kai, Yoshiteru, Abe, Satoshi, Takiguchi, Masato, Osaki, Mitsuhiko, Kanatsu- Shinohara, Mito, Kajitani, Naoyo, Shirayoshi, Yasuaki, Hiratuka, Masaharu, Ogura, Astu

Journal:

Molecular Therapy

Year:

2006

Language:

english

File:

PDF, 98 KB

english, 2006

45

The Molecular Biology of Mammalian SIRT Proteins: SIRT2 Functions on Cell Cycle Regulation

Inoue, Toshiaki, Hiratsuka, Masaharu, Osaki, Mitsuhiko, Oshimura, Mitsuo

Journal:

Year:

2007

Language:

english

File:

PDF, 481 KB

english, 2007

46

Cystathionine Is a Novel Substrate of Cystine/Glutamate Transporter

Kobayashi, Sho, Sato, Mami, Kasakoshi, Takayuki, Tsutsui, Takumi, Sugimoto, Masahiro, Osaki, Mitsuhiko, Okada, Futoshi, Igarashi, Kiharu, Hiratake, Jun, Homma, Takujiro, Conrad, Marcus, Fujii, Junichi

Journal:

Journal of Biological Chemistry

Year:

2015

Language:

english

File:

PDF, 3.47 MB

english, 2015

47

PITX1 is a reliable biomarker for predicting prognosis in patients with oral epithelial dysplasia

Osaki, Mitsuhiko

Journal:

Oncology Letters

Year:

2013

Language:

english

File:

PDF, 483 KB

english, 2013

48

Altered Expression of Cardiac Ankyrin Repeat Protein and Its Homologue, Ankyrin Repeat Protein with PEST and Proline-Rich Region, in Atrophic Muscles in Amyotrophic Lateral Sclerosis

Nakamura, Kyoko, Nakada, Chisato, Takeuchi, Kengo, Osaki, Mitsuhiko, Shomori, Kohei, Kato, Shinsuke, Ohama, Eisaku, Sato, Kenzo, Fukayama, Masashi, Mori, Shigeo, Ito, Hisao, Moriyama, Masatsugu

Journal:

Year:

2002

Language:

english

File:

PDF, 477 KB

english, 2002

49

MCM2 and Ki-67 Expression in Human Lung Adenocarcinoma: Prognostic Implications

Hashimoto, Kiyoshi, Araki, Kunio, Osaki, Mitsuhiko, Nakamura, Hiroshige, Tomita, Katsuyuki, Shimizu, Eiji, Ito, Hisao

Journal:

Year:

2004

Language:

english

File:

PDF, 950 KB

english, 2004

50

miRNA therapy targeting cancer stem cells: a new paradigm for cancer treatment and prevention of tumor recurrence

Osaki, Mitsuhiko, Okada, Futoshi, Ochiya, Takahiro

Journal:

Therapeutic Delivery

Year:

2015

Language:

english

File:

PDF, 2.38 MB

english, 2015

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